| 名称 | c-Kit L576P/BaF3 |
| 型号 | CBP73298 |
| 报价 |  |
| 特点 | c-Kit L576P/BaF3,母细胞：BaF3，冻存条件：90% FBS+10% DMSO；KIT L576P 位于 Kit 蛋白 （PMID: 17372901） 的近膜结构域（外显子 11）内。 L576P 赋予 Kit 功能增益，如 Kit 的组成性磷酸化所示，并且正在细胞培养中转化（PMID：17372901）。 |
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药靶细胞株 > kinase激酶细胞株 > CBP73298c-Kit L576P/BaF3
- 详细内容
CBP73298 | |
| I. Introduction | |
Cell Line Name： | c-Kit L576P/BaF3 |
Host Cell: | Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Application: | Anti-proliferation assay and PD assay |
Freeze Medium: | 90% FBS+10% DMSO |
Complete Culture Medium: | RPMI-1640+10%FBS |
Mycoplasma Status: | Negative |
| II.Background | |
KIT L576P lies within the juxtamembrane domain (exon 11) of the Kit protein (PMID: 17372901). L576P confers a gain of function to Kit, as indicated by constitutive phosphorylation of Kit, and is transforming in cell culture (PMID: 17372901). | |
| III. Representative Data | |
1. WB of c-Kit L576P/BaF3
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2. Sanger of c-Kit L576P/BaF3
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3. Anti-proliferation assay | |
| |
Figure 3. CTG Proliferation Assay of BaF3 c-KIT L576P (C6). | |
