| 名称 | CSF3R S783fs/BaF3 |
| 型号 | CBP73255 |
| 报价 |  |
| 特点 | CSF3R S783fs/BaF3,母细胞：BaF3，CSF3R，集落刺激因子 3 受体，编码调节骨髓祖细胞增殖和分化的细胞因子受体（PMID：27789332）。 CSF3R 突变常见于慢性中性粒细胞白血病和急性髓系白血病（PMID：23896413，PMID：30348809）。 |
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药靶细胞株 > kinase激酶细胞株 > CBP73255CSF3R S783fs/BaF3
- 详细内容
CBP73255 | |
| I. Introduction | |
Cell Line Name： | CSF3R S783fs/BaF3 |
Host Cell: | Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Application: | Anti-proliferation assay and PD assay |
Freeze Medium: | 90% FBS+10% DMSO |
Complete Culture Medium: | RPMI-1640+10%FBS |
Mycoplasma Status: | Negative |
| II.Background | |
CSF3R S783fs results in a change in the amino acid sequence of the Csf3r protein beginning at aa 783 of 836, likely resulting in premature truncation of the functional protein (UniProt.org). S783fs does not result in increased Stat3 activation (PMID: 23656643, PMID: 24403076), however, results in increased Src activation and transformation in cell culture (PMID: 23656643), and therefore, is predicted to result in a gain of Csf3r protein function. | |
| III. Representative Data | |
1.WB of CSF3R S783fs/BaF3
| |
2. Anti-proliferation assay | |
| |
Figure 2. Anti-proliferation assay of three reference compounds on the CSF3R S783fs/BaF3. | |
