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药靶细胞株 > kinase激酶细胞株 > CBP73218EGFR D770_N771insY/BaF3
![EGFR D770_N771insY/BaF3](http://img80.chem17.com/gxhpic_a89b1029a6/fd9c5b6de14e75b1eafd7ea18ebce581b3ffb67da0e34310505290994c621a9eb8eec7d9fa03e8d2.jpg)
- 详细内容
CBP73218 | |
I. Introduction | |
Cell Line Name: | EGFR D770_N771insY/BaF3 |
Host Cell: | Ba/F3 |
Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Application: | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
Freeze Medium: | 90% FBS+10% DMSO |
Complete Culture Medium: | RPMI-1640+10%FBS |
Mycoplasma Status: | Negative |
II.Background | |
EGFR D770_N771insY results in the insertion of a tyrosine (Y) in the protein kinase domain of the Egfr protein between amino acids 770 and 771 (UniProt.org). D770_N771insY has not been biochemically characterized, but is predicted to result in a gain of function based on the effect of other Egfr exon 20 insertions (PMID: 24353160). | |
III. Representative Data | |
1. WB of EGFR D770_N771insY/BaF3
| |
2. Anti-proliferation assay |