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药靶细胞株 > 免疫治疗细胞株 > CBP74106ADCP Bioassay Effector Cell FcγRIIa (H variant)-NF

ADCP Bioassay Effector Cell FcγRIIa (H variant)-NF
名称 ADCP Bioassay Effector Cell FcγRIIa (H variant)-NF
型号 CBP74106
报价
特点 ADCP Bioassay Effector Cell FcγRIIa (H variant)-NFAT/Jurkat,母细胞:Jurkat,冻存条件:90% FBS+10% DMSO
  • 详细内容

 

CBP74106
I. Background

Antibody-dependent cell-mediated phagocytosis (ADCP) is one of the important mechanisms of action for antibody drug development. FcγRIIa is the predominant Fcγ receptor involved in the ADCP process. FcγRIIa is expressed in myeloid effector cells, including macrophages and neutrophils, where it plays a role in the activation of these effector cells. Several clinical studies have studied the correlation of a FcγRIIa polymorphism (R131H) and the response to IgG1 subclass monoclonal antibodies (mAbs) such as rituximab. Engineered amino-acid substitutions in Fc-mAbs have been developed to enhance the mAb-mediated phagocytosis of tumor cells by macrophages.

 
II. Description

Recombinant Jurkat T cell expressing a firefly luciferase gene under the control of NFAT response elements with constitutive expression of human FcγRIIa, Histidine variant.

 
III. Introduction
Host Cell:Jurkat
Expressed gene:FcγRIIa (H variant)-NFAT
Stability:32 passages
Synonym(s):N/A
Freeze Medium:90% FBS+10% DMSO
Culture Medium: 
Storage:Immediately upon receipt, store in liquid nitrogen.
Application(s):Characterize the Fc effector function of antibodies.
 
IV. Description of Host Cell Line
Organism:Human
Tissue:Peripheral blood
Disease: Childhood T acute lymphoblastic leukemia
Morphology: Lymphoblast
Growth Properties: Suspension
 
Ⅴ. Representative Data

CBP74106.png

 Figure 1:Dose response of Rituximab in ADCP Bioassay Effector Cell FcyRlla (H variant) /NFAT Reporter-Jurkat (C2),the EC50 was 21.5ng/ml.

  

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