名称 | CD155/TCR Activator/CHO |
型号 | CBP74073 |
报价 | ![]() |
特点 | CD155/TCR Activator/CHO,冻存条件:90% FBS+10% DMSO |
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Email: duhaitao@cobioer.com
电话:86-25-86880024
号码:86-25-86880024
手机:18066071954
地址:南京市雨花区长虹路222号
Email: duhaitao@cobioer.com
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- 详细内容
CBP74073 | |
I. Background | |
TIGIT is a co-inhibitory receptor that is highly expressed in Natural Killer (NK) cells, activated CD4+, CD8+ and regulatory T cells. Interaction with the poliovirus receptor (PVR; CD155) on antigen presenting cells, such as dendritic cells, recruits Src homology (SH) domain-containing protein tyrosine phosphatase SHP1 and SHP2 or the inositol phosphatase SHIP1 and SHIP2 to the TIGIT ITIM domain. This increases IL-10 release and suppresses NF-kB and NFAT T cell receptor (TCR) signaling, which blocks T cell proliferation and cytokine production. It serves as a competitive inhibitor of CD226, a co-stimulatory receptor for CD155. TIGIT targeting antibodies that block this T cell-intrinsic inhibitory effects have shown enhanced anti-tumor and anti-viral functions in preclinical studies. | |
II. Description | |
Recombinant CHO-K1 cells constitutively expressing human CD155 (Poliovirus receptor, Nectin-like protein 5, GenBank accession # NM_006505) and an engineered T cell receptor (TCR) activator. | |
III. Introduction | |
Host Cell: | CHO |
Expressed gene: | CD155 |
Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Synonym(s): | Poliovirus receptor, Nectin-like protein 5, CD155-His |
Freeze Medium: | 90% FBS+10% DMSO |
Culture Medium: | 1640+10%FBS+800ug/ml hygromycin+1ug/ml puromycin |
Mycoplasma Testing: | Negative |
Storage: | Liquid nitrogen |
Application(s): | Screen for activators or inhibitors of TIGIT signaling in a cellular context, screen CD155 antibodies for binding affinity, and characterize the biological activity of TIGIT interactions with CD155. |
IV. Description of Host Cell Line | |
Organism: | Cricetulus griseus, hamster, Chinese |
Tissue: | Ovary |
Disease: | Hamster Chinese ovary |
Morphology: | Epitheloid cell |
Growth Properties: | Adherent |
Ⅴ. Representative Data | |
Figure 1.Recombinant CHO-cells constitutively expressing CD155 and an engineered T cell receptor (TCR) activator. | |
Figure 2. Figure 2. Dose response of anti-TIGIT neutralizing antibody in TIGIT /NFAT-Reporter Jurkat cell line (C26) with CD155/ TCR activator - CHO. | |