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药靶细胞株 > 免疫治疗细胞株 > CBP74033CD27/CHO

CD27/CHO
名称 CD27/CHO
型号 CBP74033
报价
特点 CD27/CHO,冻存条件:90% FBS+10% DMSO,培养基:F12k+10%FBS+5ug/ml puromycin
  • 详细内容
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CBP74033
I. Background
CD27 is a member of the tumor necrosis factor (TNF) receptor superfamily, which includes the T cell co-stimulatory receptors OX40, 4-1BB and herpesvirus entry mediator (HVEM). CD27 is expressed on various types of T cells, B cells and a subset of natural killer cells. It activates NF- kB and MAPK/JNK signaling upon interaction with its TNF-like ligand, CD70, which is expressed by numerous tumor cells. Adaptor proteins TRAF2 and TRAF5 can also stimulate CD27 signaling. Activation of CD27 leads to lymphoid proliferation, differentiation, apoptosis, and the induction of long-term memory. The CD27/CD70 pathway is a key target for the development of treatments for cancer and inflammatory diseases.
 
II. Description

CHO cell line expressing full length human CD27 (TNFRSF7). Expression is confirmed by real time qPCR, Western blot, and flow cytometry.

Screening for antibodies recognizing CD27 and screening antibodies for binding affinities. Since
CHO cells do not express endogenous CD27, this cell line serves as an excellent model for
studying changes in CD27-mediated signaling pathways, such as NF-kB, MAPK and
SAPK/JNK.

 
III. Introduction
Host Cell:CHO
Expressed gene:CD27
Stability:32 passages
Synonym(s):CD70 antigen, Tumor Necrosis Factor Ligand Superfamily Member 7, TNFSF7, CD27 Ligand, Ki-24 antigen, CD27-L, CD27LG
Freeze Medium:90% FBS+10% DMSO
Culture Medium:

F12k+10%FBS+5ug/ml puromycin

Storage:Liquid nitrogen
 
IV. Description of Host Cell Line
Organism:Cricetulus griseus, hamster, Chinese
Tissue:Ovary
Disease: Hamster Chinese ovary
Morphology: Epitheloid cell
Growth Properties: Adherent
 
Ⅴ. Representative Data

CBP74033.png

Figure 1. CHO cell line expressing full length human CD27 (TNFRSF7). Expression is confirmed by flow cytometry.


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