加入收藏 | 设为首页 | 联系我们

产品搜索

相关文章

联系我们

联系人:蒋经理
电话:86-25-86880024
号码:86-25-86880024
手机:18066071954
地址:南京市雨花区长虹路222号
Email: duhaitao@cobioer.com

产品展示 / PRODUCTS
药靶细胞株 > 肿瘤免疫细胞株 > CBP74039CD27/HEK293

CD27/HEK293
名称 CD27/HEK293
型号 CBP74039
报价
特点 CD27/HEK293,冻存条件:90% FBS+10% DMSO
  • 详细内容
CBP74039
I. Background
CD27 is a member of the tumor necrosis factor (TNF) receptor superfamily, which includes the T cell co-stimulatory receptors OX40, 4-1BB and herpesvirus entry mediator (HVEM). CD27 is expressed on various types of T cells, B cells and a subset of natural killer cells. It activates NF- kB and MAPK/JNK signaling upon interaction with its TNF-like ligand, CD70, which is expressed by numerous tumor cells. Adaptor proteins TRAF2 and TRAF5 can also stimulate CD27 signaling. Activation of CD27 leads to lymphoid proliferation, differentiation, apoptosis, and the induction of long-term memory. The CD27/CD70 pathway is a key target for the development of treatments for cancer and inflammatory diseases.

II. Description

HEK293 cell line expressing full length human CD27 (TNFRSF7). Expression is confirmed by real time qPCR, Western blot, and flow cytometry.

Screening for antibodies recognizing CD27 and screening antibodies for binding affinities. Since

HEK293 cells do not express endogenous CD27, this cell line serves as an excellent model for

studying changes in CD27-mediated signaling pathways, such as NF-kB, MAPK and

SAPK/JNK.


III. Introduction
Host Cell:HEK293
Expressed gene:CD-27
Stability:32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Synonym(s):CD70 antigen, Tumor Necrosis Factor Ligand Superfamily Member 7, TNFSF7, CD27 Ligand, Ki-24 antigen, CD27-L, CD27LG
Freeze Medium:90% FBS+10% DMSO
Culture Medium:

DMEM +10%FBS+1ug/ml puromycin

Storage:Liquid nitrogen

IV. Description of Host Cell Line
Organism:Homo sapiens, human
Tissue:Embryonic kidney
Disease: Normal
Morphology: Epitheloid cell
Growth Properties: Adherent

Ⅴ. Representative Data

CBP74039.png

Figure 1. HEK293 cell line expressing full length human CD27 (TNFRSF7). Expression is confirmed by flow cytometry.



如果你对CBP74039CD27/HEK293感兴趣,想了解更详细的产品信息,填写下表直接与厂家联系:


留言框

  • 产品:

  • 您的单位:

  • 您的姓名:

  • 联系电话:

  • 常用邮箱:

  • 省份:

  • 详细地址:

  • 补充说明:

  • 验证码:

    请输入计算结果(填写阿拉伯数字),如:三加四=7
QQ在线客服
电话咨询
  • 25-86880024
  • 手机:18066071954

化工仪器网

推荐收藏该企业网站
扫一扫访问手机站扫一扫访问手机站
访问手机站