| 名称 | CSF1R/HEK293 |
| 型号 | CBP74048 |
| 报价 |  |
| 特点 | CSF1R/HEK293，冻存条件：90% FBS+10% DMSO |
产品搜索
相关文章
联系我们
联系人：蒋经理
电话：86-25-86880024
号码：86-25-86880024
手机：18066071954
地址：南京市雨花区长虹路222号
Email： duhaitao@cobioer.com
电话：86-25-86880024
号码：86-25-86880024
手机：18066071954
地址：南京市雨花区长虹路222号
Email： duhaitao@cobioer.com
产品展示 / PRODUCTS
- 详细内容
| CBP74048 | |
| I. Background | |
| Colony Stimulating Factor 1 Receptor (CSF1R, CSFR, CD115, M-CSF-R) is a single-pass tyrosine kinase transmembrane receptor which is part of the type III protein tyrosine kinase receptor family. CSF1R is activated by either of two cytokines, CSF1 (MCSF; CSF-1) and IL-34 (IL34), causing homodimerization and activation of downstream kinase activity. CSF1R is expressed on the surface of monocytes and macrophages, and its activation controls the growth, function, and differentiation of macrophages. This interaction is used by numerous cancer types, such as diffuse-type tenosynovial giant cell tumors (dt-GCT), to evade the immune system. By overexpressing the cytokine CSF1, these cells drive the development and survival of Tumor-Associated Macrophages (TAMs), which in turn suppress the local immune response to the cancer. | |
| II. Description | |
| Recombinant HEK293 stably expressing human CSF1R (full-length human CSF1R cDNA (NP_005202) ). | |
| III. Introduction | |
| Host Cell: | HEK293 |
| Expressed gene: | CSF1R |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Synonym(s): | CSF1R, CSFR, CD115, M-CSF-R |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+1ug/ml puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Immediately upon receipt, store in liquid nitrogen. |
| Application(s): | CSF1R binding molecule (such as anti-CSF1R antibody) screening and profiling in a cellular context |
| IV. Description of Host Cell Line | |
| Organism: | Homo sapiens,human |
| Tissue: | Embryonic kidney |
| Disease: | Normal |
| Morphology: | Epitheloid cell |
| Growth Properties: | Adherent |
| Ⅴ. Representative Data | |
| |
Figure 1. Recombinant HEK293 stably expressing human CSF1R (full-length human CSF1R cDNA (NP_005202) ). | |
