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药靶细胞株 > 肿瘤免疫细胞株 > CBP74048CSF1R/HEK293

CSF1R/HEK293
名称 CSF1R/HEK293
型号 CBP74048
报价
特点 CSF1R/HEK293,冻存条件:90% FBS+10% DMSO
  • 详细内容



CBP74048
I. Background
Colony Stimulating Factor 1 Receptor (CSF1R, CSFR, CD115, M-CSF-R) is a single-pass tyrosine kinase transmembrane receptor which is part of the type III protein tyrosine kinase receptor family. CSF1R is activated by either of two cytokines, CSF1 (MCSF; CSF-1) and IL-34 (IL34), causing homodimerization and activation of downstream kinase activity. CSF1R is expressed on the surface of monocytes and macrophages, and its activation controls the growth, function, and differentiation of macrophages. This interaction is used by numerous cancer types, such as diffuse-type tenosynovial giant cell tumors (dt-GCT), to evade the immune system. By overexpressing the cytokine CSF1, these cells drive the development and survival of Tumor-Associated Macrophages (TAMs), which in turn suppress the local immune response to the cancer.

II. Description
Recombinant HEK293 stably expressing human CSF1R (full-length human CSF1R cDNA (NP_005202) ).

III. Introduction
Host Cell:HEK293
Expressed gene:CSF1R
Stability:32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Synonym(s):CSF1R, CSFR, CD115, M-CSF-R
Freeze Medium:90% FBS+10% DMSO
Culture Medium:

DMEM+10%FBS+1ug/ml puromycin

Mycoplasma Testing:Negative
Storage:Immediately upon receipt, store in liquid nitrogen.
Application(s):CSF1R binding molecule (such as anti-CSF1R antibody) screening and profiling in a cellular context

IV. Description of Host Cell Line
Organism:Homo sapiens,human
Tissue:Embryonic kidney
Disease: Normal
Morphology: Epitheloid cell
Growth Properties: Adherent

Ⅴ. Representative Data

CBP74048.png


Figure 1. Recombinant HEK293 stably expressing human CSF1R (full-length human CSF1R cDNA (NP_005202) ).



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