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药靶细胞株 > GPCR细胞株 > CBP71357CXCR2/CHO

CXCR2/CHO
名称 CXCR2/CHO
型号 CBP71357
报价
特点 CXCR2/CHO 冻存条件:90% FBS+10% DMSO
  • 详细内容
CBP71357
I. Background

The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein-activated second messenger system (Gi/o-coupled[6]). This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. In addition, it binds ligands CXCL2, CXCL3, and CXCL5.


II. Introduction
Host Cell:

CHO

Stability:20 passages
Freeze Medium:90% FBS+10% DMSO
Culture Medium:F12K+10%FBS+5ug/ml puromycin
Mycoplasma Status:Negative
Storage:Liquid nitrogen immediately upon delivery
Application(s):

Functional assay for CXCR2 receptor

Transducer:N/A

Ⅲ. Description of Host Cell Line
Organism:Hamster
Tissue:Ovary
Morphology: Epithelial
Growth Properties: Adherent

Ⅳ. Representative Data

Figure 2. IL -8 effect on CXCR2/CHO-K1 clone 7.




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