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基因检测标准品 > 其他类别 > CBP80001-9tTMB-P9(matrix) Reference Standard

tTMB-P9(matrix) Reference Standard
名称 tTMB-P9(matrix) Reference Standard
型号 CBP80001-9
报价
特点 tTMB-P9(matrix) Reference Standard
  • 详细内容
CBP80001-9
I. Background

Tumor mutational burden (TMB) shows great promise as a biomarker for immuno-oncology (I-O) therapy response, but progress is hindered by the lack of a standardized TMB measurement by targeted NGS panels, and an absence of TMB reference materials.

 

Sample ID

Description

Cut off=1%

Cut off=2%

Cut off=3%

Cut off=4%

Cut off=5%

DC208D0421

10%T+90%N

22.94

19.72

16.53

12.50

8.41

DC208D0422

5%T+95%N

15.75

10.50

5.82

2.92

1.37

DC208D0423

2%T+98%N

8.29

2.12

0.75

0.42

0.21

DC208D0424

1%T+99%N

4.15

0.95

0.27

0.18

0.09

500xWES;
IDT xGenExome Research Panel v1.0捕获,Target Region 39M, Probe Region 51M;
HiSeq X-TEN,af选择0.01 cut off,call突变,再过滤,然后在按照梯度cut off计算TMB。
Tumor sample: stage 4, adenocarcinoma Lung, Female
Normal sample: B lymphoblast from the same individual

 

计算数据下载:

DC208D0421.filter.0.01.tag

DC208D0423.filter.0.01.tag

DC208D0421.filter.0.02.tag

DC208D0423.filter.0.02.tag

DC208D0421.filter.0.03.tag

DC208D0423.filter.0.03.tag

DC208D0421.filter.0.04.tag

DC208D0423.filter.0.04.tag

DC208D0421.filter.0.05.tag

DC208D0423.filter.0.05.tag

DC208D0422.filter.0.01.tag

DC208D0424.filter.0.01.tag

DC208D0422.filter.0.02.tag

DC208D0424.filter.0.02.tag

DC208D0422.filter.0.03.tag

DC208D0424.filter.0.03.tag

DC208D0422.filter.0.04.tag

DC208D0424.filter.0.04.tag

DC208D0422.filter.0.05.tag

DC208D0424.filter.0.05.tag

 

 
 
 
 

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