| 名称 | ALK p.F1174L Reference Standard |
| 型号 | CBP10225 |
| 报价 |  |
| 特点 | ALK p.F1174L Reference Standard |
产品搜索
相关文章
联系我们
联系人：蒋经理
电话：86-25-86880024
号码：86-25-86880024
手机：18066071954
地址：南京市雨花区长虹路222号
Email： zhangxiangwen@cobioer.com
电话：86-25-86880024
号码：86-25-86880024
手机：18066071954
地址：南京市雨花区长虹路222号
Email： zhangxiangwen@cobioer.com
产品展示 / PRODUCTS
- 详细内容
CBP10225 | |
| Format | Genomic DNA |
| Description | ALK F1174L lies within the protein kinase domain of the Alk protein (UniProt.org). F1174L confers a gain of function to the Alk protein as indicated by transformation activity and increased cell proliferation in culture (PMID: 18923525, PMID: 29533785, PMID: 29907598), and has been demonstrated to occur as a secondary resistance mutation in the context of ALK fusions (PMID: 21030459). |
| Technical Data | |
| DNA Change | c.3522C>A |
| AA Change | p.F1174L |
| Mutation type | Substitution - Missense |
| Zygosity | Heterozygous |
| Allelic Frequency | 33.33% |
| Transcript | ENST00000389048 |
| Cosmic ID | COSM28055 |
| Chr position(GRCh37) | chr2:29443695 |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |
|
| Storage | 4℃ |
| Expiry | 36 months from the date of manufacture |
