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基因检测标准品 > Mutation > CBP10422FGFR3 p.S249C Reference Standard 标准品

FGFR3 p.S249C Reference Standard 标准品
名称 FGFR3 p.S249C Reference Standard 标准品
型号 CBP10422
报价
特点 FGFR3 p.S249C Reference Standard
  • 详细内容
 CBP10422
FormatGenomic DNA
DescriptionFGFR3, fibroblast growth factor receptor 3, is a receptor tyrosine kinase activated upon binding of the FGF ligand, which activates RAS-MAPK and PI3K-AKT pathways (PMID: 22508544). Altered function of FGFR3 in cancer may lead to increased cell proliferation and decreased apoptosis (PMID: 22508544) and mutations and fusions are commonly observed in bladder cancer (PMID: 30975452, PMID: 23175443).
  
Technical Data 
DNA Change:c.746C>G
AA Changep.S249C
Mutation typeSubstitution - Missense
ZygosityHeterozygous
Allelic Frequency85.00%
TranscriptNM_000142.5
Cosmic IDCOSM715
Chr position(GRCh37)chr4:1803568
Buffer:Tris-EDTA
  
Product Information 
Intended UseResearch Use Only
Unit Size1ug
ConcentrationDownload for COA
PurityDownload for COA
DNA electrophoresisDownload for COA
Sanger sequencing

CBP10422.png

Storage4℃
Expiry36 months from the date of manufacture

 

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