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基因检测标准品 > Mutation > CBP10305MAP2K1 p.P124S Reference Standard 标准品

MAP2K1 p.P124S Reference Standard 标准品
名称 MAP2K1 p.P124S Reference Standard 标准品
型号 CBP10305
报价
特点 MAP2K1 p.P124S Reference Standard
  • 详细内容

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 CBP10305
FormatGenomic DNA
DescriptionMAP2K1 P124S lies within the protein kinase domain of the Map2k1 protein (UniProt.org). The functional effect of P124S is conflicting, as P124S has been reported to confer a gain of function on the Map2k1 protein as demonstrated by increased ERK1/2 phosphorylation, but has similar induction of cell proliferation and viability levels as wild-type Map2k1 (PMID: 29533785), and also confers resistance to Mek and Braf inhibitors in melanoma cells (PMID: 19915144, PMID: 22197931),
  
Technical Data 
DNA Changec.370C>T
AA Changep.P124S
Mutation typeSubstitution - Missense
ZygosityHeterozygous
Allelic Frequency50.00%
TranscriptENST00000307102
Cosmic IDCOSM235614
Chr position(GRCh37)chr15:66729162
BufferTris-EDTA
  
Product Information 
Intended UseResearch Use Only
Unit Size1ug
ConcentrationDownload for COA
PuroficationDownload for COA
DNA electrophoresisDownload for COA
Sanger sequencing

CBP10305.png

Storage4℃
Expiry36 months from the date of manufacture

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