名称 | PIK3CA p.R38C Reference Standard 标准品 |
型号 | CBP10111 |
报价 | |
特点 | PIK3CA p.R38C Reference Standard |
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CBP10111 | |
Format | Genomic DNA |
Description | PIK3CA R38C lies within the PI3K-ABD domain of the Pik3ca protein (UniProt.org). R38C confers a gain of function to Pik3ca, as indicated by increased phosphorylation of downstream targets Akt, GSK3-beta, FoxO1, FoxO3a, and S6 in cell culture (PMID: 18829572) and demonstrates increased transformation ability in two different cell lines, as compared to wild-type Pik3ca (PMID: 29533785). |
Technical Data | |
DNA Change: | c.112C>T |
AA Change | p.R38C |
Mutation type | Substitution - Missense |
Zygosity | Heterozygous |
Allelic Frequency | 50.00% |
Transcript | ENST00000263967 |
Cosmic ID | COSM744 |
Chr position(GRCh37) | chr3:178916725 |
Buffer: | Tris-EDTA |
Product Information | |
Intended Use | Research Use Only |
Unit Size | 1ug |
Concentration | Download for COA |
Purofication | Download for COA |
DNA electrophoresis | Download for COA |
Sanger sequencing | |
Storage | 4℃ |
Expiry | 36 months from the date of manufacture |