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基因检测标准品 > Mutation > CBP10111PIK3CA p.R38C Reference Standard 标准品

PIK3CA p.R38C Reference Standard 标准品
名称 PIK3CA p.R38C Reference Standard 标准品
型号 CBP10111
报价
特点 PIK3CA p.R38C Reference Standard
  • 详细内容

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 CBP10111
FormatGenomic DNA
DescriptionPIK3CA R38C lies within the PI3K-ABD domain of the Pik3ca protein (UniProt.org). R38C confers a gain of function to Pik3ca, as indicated by increased phosphorylation of downstream targets Akt, GSK3-beta, FoxO1, FoxO3a, and S6 in cell culture (PMID: 18829572) and demonstrates increased transformation ability in two different cell lines, as compared to wild-type Pik3ca (PMID: 29533785).
  
Technical Data 
DNA Change:c.112C>T
AA Changep.R38C
Mutation typeSubstitution - Missense
ZygosityHeterozygous
Allelic Frequency50.00%
TranscriptENST00000263967
Cosmic IDCOSM744
Chr position(GRCh37)chr3:178916725
Buffer:Tris-EDTA
  
Product Information 
Intended UseResearch Use Only
Unit Size1ug
ConcentrationDownload for COA
PuroficationDownload for COA
DNA electrophoresisDownload for COA
Sanger sequencing

CBP10111.png

Storage4℃
Expiry36 months from the date of manufacture

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