名称 | TP53 p.G245C Reference Standard 标准品 |
型号 | CBP10154 |
报价 | ![]() |
特点 | TP53 p.G245C Reference Standard |
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- 详细内容
CBP10154 | |
Format | Genomic DNA |
Description | TP53 G245C is a hotspot mutation that lies within the DNA binding domain of the Tp53 protein (PMID: 22713868). G245C results in a loss of transactivation of several targets of wild-type Tp53 (PMID: 22170099, PMID: 30126368), and also confers a gain-of-function to Tp53, as demonstrated through inhibition of Ampk activation in cell culture, and leads to increased tumor formation in mouse models (PMID: 24857548), and increased migration and invasion in culture (PMID: 30126368). |
Technical Data | |
DNA Change: | c.733G>T |
AA Change | p.G245C |
Mutation type | Substitution - Missense |
Zygosity | Homozygous |
Allelic Frequency | 100% |
Transcript | ENST00000269305 |
Cosmic ID | COSM11081 |
Chr position(GRCh37) | chr17:7577548 |
Buffer: | Tris-EDTA |
Product Information | |
Intended Use | Research Use Only |
Unit Size | 1ug |
Concentration | Download for COA |
Purofication | Download for COA |
DNA electrophoresis | Download for COA |
Sanger sequencing | Download for COA |
Storage | 4℃ |
Expiry | 36 months from the date of manufacture |
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