加入收藏 | 设为首页 | 联系我们

产品搜索

相关文章

联系我们

联系人:蒋经理
电话:4008750250
号码:
手机:18066071954
地址:南京市栖霞区纬地路9号
Email: zhangxiangwen@cobioer.com

产品展示 / PRODUCTS
基因检测标准品 > Mutation > CBP10153TP53 p.G245D Reference Standard 标准品

TP53 p.G245D Reference Standard 标准品
名称 TP53 p.G245D Reference Standard 标准品
型号 CBP10153
报价
特点 TP53 p.G245D Reference Standard
  • 详细内容
 CBP10153
FormatGenomic DNA
DescriptionTP53 G245D is a hotspot mutation that lies within the DNA binding domain of the Tp53 protein (PMID: 22713868). G245D results in decreased activation of Tp53 target genes (PMID: 22214764, PMID: 25634208, PMID: 27533082), and also confers a gain-of-function to Tp53 as demonstrated by aberrant interaction with ZBP-89, as well as induction of FOXM1 expression, and leads to decreased apoptosis in culture and increased tumor growth and metastasis in mouse models (PMID: 22214764, PMID: 29269868).
  
Technical Data 
DNA Change:c.734G>A
AA Changep.G245D
Mutation typeSubstitution - Missense
ZygosityHomozygous
Allelic Frequency100%
TranscriptENST00000269305
Cosmic IDCOSM43606
Chr position(GRCh37)chr17:7577547
Buffer:Tris-EDTA
  
Product Information 
Intended UseResearch Use Only
Unit Size1ug
ConcentrationDownload for COA
PuroficationDownload for COA
DNA electrophoresisDownload for COA
Sanger sequencingDownload for COA
Storage4℃
Expiry36 months from the date of manufacture

如果你对CBP10153TP53 p.G245D Reference Standard 标准品感兴趣,想了解更详细的产品信息,填写下表直接与厂家联系:


留言框

  • 产品:

  • 您的单位:

  • 您的姓名:

  • 联系电话:

  • 常用邮箱:

  • 省份:

  • 详细地址:

  • 补充说明:

  • 验证码:

    请输入计算结果(填写阿拉伯数字),如:三加四=7

化工仪器网

推荐收藏该企业网站