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药靶细胞株 > 肿瘤免疫细胞株 > CBP74178HVEM/U2OS Cell

HVEM/U2OS Cell
名称 HVEM/U2OS Cell
型号 CBP74178
报价
特点 HVEM/U2OS Cell
  • 详细内容
CBP74178
I. Background

HVEM (CD270, TNFRSF14) is a human cell surface receptor in the TNF-receptor superfamily that can act as both a co-stimulatory receptor and a co-inhibitory receptor expressed on the surface of T cells. Binding of HVEM to one of its ligands, LIGHT (CD258, TNFSF14) or LTα (lymphotoxin-α), causes a co-stimulatory signal which can activate lymphoid cells. Interaction with BTLA (CD272) or CD160 causes a co-inhibitory signal which negatively regulates T-cell immune responses. HVEM has also been shown to interact with adaptor proteins TRAF2 and TRAF5, and is critical to herpes simplex virus (HSV) cellular entry.

 
II. Introduction
Expressed gene:HVEM、U2OS 
Stability:32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Freeze Medium:90% FBS+10% DMSO
Culture Medium:N/A
Mycoplasma Testing:Negative
Storage:Liquid nitrogen
Application(s):Functional(Report Gene) Assay
 
III. Representative Data

CBP74178.jpg

Figure 1. Inhibtion of HVEM Induced SHP2 Recruitment In BTLA/SHP2 Reporter Cells (C11) By Samples With HVEM/U2OS Cells (C7).

 

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