名称 | HVEM/U2OS Cell |
型号 | CBP74178 |
报价 | ![]() |
特点 | HVEM/U2OS Cell |
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![HVEM/U2OS Cell](http://img80.chem17.com/gxhpic_a89b1029a6/fd9c5b6de14e75b1fb123653623121a25496c3d2fc187e2d898156e7a0eee0305aca001b265ad145.jpg)
- 详细内容
CBP74178 | |
I. Background | |
HVEM (CD270, TNFRSF14) is a human cell surface receptor in the TNF-receptor superfamily that can act as both a co-stimulatory receptor and a co-inhibitory receptor expressed on the surface of T cells. Binding of HVEM to one of its ligands, LIGHT (CD258, TNFSF14) or LTα (lymphotoxin-α), causes a co-stimulatory signal which can activate lymphoid cells. Interaction with BTLA (CD272) or CD160 causes a co-inhibitory signal which negatively regulates T-cell immune responses. HVEM has also been shown to interact with adaptor proteins TRAF2 and TRAF5, and is critical to herpes simplex virus (HSV) cellular entry. | |
II. Introduction | |
Expressed gene: | HVEM、U2OS |
Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Freeze Medium: | 90% FBS+10% DMSO |
Culture Medium: | N/A |
Mycoplasma Testing: | Negative |
Storage: | Liquid nitrogen |
Application(s): | Functional(Report Gene) Assay |
III. Representative Data | |
Figure 1. Inhibtion of HVEM Induced SHP2 Recruitment In BTLA/SHP2 Reporter Cells (C11) By Samples With HVEM/U2OS Cells (C7). | |