CCR6/β-Arrestin/CHO GPCR细胞-南京科佰生物科技有限公司

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CBP71406
I. Background
CCR6 is a CC chemokine receptor that is selectively expressed in immature dendritic cells and memory T-cells. It primarily couples through Gi/o proteins upon activation. CCR6 plays an important role on skin and mucosal surfaces under homeostatic and inflammatory conditions, particularly through the recruitment of proinflammatory IL17-producing T-cells to sites of inflammation. Therefore, CCR6 is a potential target for several inflammatory and autoimmune diseases including psoriasis and inflammatory bowel disease. In human and mouse, CCR6 is exclusively activated by the chemokine CCL20, which is known to interact only with CCR6.

II. Introduction
Host Cell:	CHO
Stability:	20 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Freeze Medium:	90% FBS+10% DMSO
Culture Medium:	F12K+10%FBS+5ug/ml puromycin+5ug/ml blastcidin
Mycoplasma Status:	Negative
Storage:	Liquid nitrogen immediately upon delivery
Application(s):	Functional assay for CCR6 receptor
Assay Format:	β-arrestin recruitment

Ⅲ. Description of Host Cell Line
Organism:	Hamster
Tissue:	Ovary
Morphology:	Epithelial
Growth Properties:	Adherent

Ⅳ. Representative Data
Figure 1. Recombinant CCR6/β-Arrestin/CHO constitutively expressing CCR6.
Figure 2. Dose response of Human CCL20 in CCR6 β-Arrestin CHO-K1 Cell Line (C33).