名称 | GLP1R&GIPR Dual Reporter Cell |
型号 | CBP71499 |
报价 | ![]() |
特点 | GLP1R&GIPR Dual Reporter Cell |
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GLP1R&GIPR Dual Reporter Cell GLP1R&GIPR Dual Reporter Cell
I. Background | |
GLP-1R 与其他四种胰高血糖素受体(GCGR、GLP-2R、GIPR 和 GHRHR)一起属于 促胰液素(B1 类)GPCR 家族,其内源性配体是肽激素。 B1 类 GPCRs 在 N 端具有一个 较大的、结构保守的胞外结构域(ECD),由 120-160 个残基组成,形成三层 α-β-β-α 折叠, 并由三个层间二硫键稳定。 | |
II. Description | |
GLP1R&GIPR Dual Reporter Cell 报告基因药靶模型很好的模拟了体内 GLP1R&GIPR的信号转导过程,原理见下图所示。。 Figure 1. GLP1R&GIPR Dual Reporter Cell 细胞模型原理图
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III. Introduction | |
Expressed gene: | GLP1R&GIPR |
Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Freeze Medium: | 90% FBS+10% DMSO |
Culture Medium: | DMEM+10%FBS+ 2 μg/ml puro+ 5 μg/ml Blasticidin+ 200 μg/ml Hygromycin B |
Mycoplasma Testing: | Negative |
Storage: | Liquid nitrogen |
Application(s): | Functional assay for GLP1R&GIPR |
Transducer: | Gs |
IV. Representative Data![]()
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Figure 3. Dose response of Agonists in GLP1R&GIPR Dual Reporter Cell(C43).
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