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药靶细胞株 > kinase激酶细胞株 > CBP73229CSF1R(CSF1 Dependent)/BaF3

CSF1R(CSF1 Dependent)/BaF3
名称 CSF1R(CSF1 Dependent)/BaF3
型号 CBP73229
报价
特点 CSF1R(CSF1 Dependent)/BaF3,母细胞:BaF3,培养基:1640+10%FBS+0.1ug/ml M-CSF
  • 详细内容

 

CBP73229
I. Introduction

Cell Line Name:

CSF1R(CSF1 Dependent)/BaF3

Gene Synonyms:

CSF1R, CSFR, CD115, M-CSF-R

Host Cell:

Ba/F3

Stability:16 passages

Application:

Monitor the CSF1R/MAPK/ERK signaling pathway activity and SRF-mediated activity. Screen for activators or inhibitors of the CSF1R/MAPK/ERK signaling pathway.

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

1640+10%FBS+0.1ug/ml M-CSF

Mycoplasma Status:

Negative

 
II.Background

CSF1R is activated by either of two cytokines, CSF1 (MCSF; CSF-1) and IL-34 (IL34), causing homodimerization and activation of downstream kinase activity. CSF1R is expressed on the surface of monocytes and macrophages, and its activation controls the growth, function, and differentiation of macrophages. This interaction is used by numerous cancer types, such as diffuse-type tenosynovial giant cell tumors (dt-GCT), to evade the immune system. By overexpressing the cytokine CSF1, these cells drive the development and survival of Tumor-Associated Macrophages (TAMs), which in turn suppress the local immune response to the cancer.

 
III. Representative Data

Anti-proliferation assay

 

CBP73229 fig1.png


 

Figure 2. Anti-proliferation assay of two reference compounds on the CSF1R(CSF1 Dependent)/BaF3 Stable Cell Line.

 

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