EGFR VIII/BaF3-南京科佰生物科技有限公司

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联系人：蒋经理
电话：86-25-86880024
号码：86-25-86880024
手机：18066071954
地址：南京市雨花区长虹路222号
Email： zhangxiangwen@cobioer.com

名称	EGFR VIII/BaF3
型号	CBP73226
报价
特点	EGFR VIII/BaF3,母细胞：BaF3，冻存条件：90% FBS+10% DMSO

CBP73226
I. Introduction
Cell Line Name：	EGFR VIII/BaF3
Host Cell:	Ba/F3
Stability:	16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Application:	Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Freeze Medium:	90% FBS+10% DMSO
Complete Culture Medium:	RPMI-1640+10%FBS
Mycoplasma Status:	Negative

II.Background
EGFR (HER1), epidermal growth factor receptor, is a tyrosine kinase receptor, which activates RAS/RAF/MEK and PI3K/AKT/mTOR pathways, leading to increased cell proliferation and growth (PMID: 24312144). EGFR activating mutations, amplification, and overexpression are found in a variety of tumors, including non-small cell lung cancer (PMID: 26609494, PMID: 30284706) and colorectal cancer (PMID: 30243897), and the EGFRvIII variant is commonly found in glioblastoma (PMID: 30201736).

III. Representative Data
1. Anti-proliferation assay Figure . Anti-proliferation assay of three reference compounds on the EGFR VIII/BaF3 Stable Cell Line .