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药靶细胞株 > 肿瘤免疫细胞株 > CBP74038OX40/CHO

OX40/CHO
名称 OX40/CHO
型号 CBP74038
报价
特点 OX40/CHO,冻存条件:90% FBS+10% DMSO;
  • 详细内容
CBP74038
I. Background
OX40 (CD134) is a co-stimulatory receptor expressed on the surface of CD4+ and CD8+ T cells 24 to 48 hours after activation. Binding of OX40 to its ligand, OX40L (CD252), present on dendritic cells, potentiates T cell survival and increases cytokine production. OX40 has been shown to activate NF-κB-mediated memory cell generation through its interaction with adaptor proteins TRAF2 and TRAF5. OX40 has a critical role in the maintenance of an immune response beyond the first few days and onwards to a memory response.

II. Description

Recombinant CHO stably expressing human OX40 (TNF receptor superfamily member 4, TNFRSF4, ACT35; CD134; IMD16; TXGP1L, GenBank Accession #NM_003327).


III. Introduction
Host Cell:CHO
Expressed gene:OX-40
Stability:32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Synonym(s):TNFRSF4, ACT35, IMD16, TXGP1L, Tumor Necrosis Factor Receptor Superfamily Member 4, TNFRSF4, CD134
Freeze Medium:90% FBS+10% DMSO
Culture Medium:

F12k+10%FBS+5ug/ml puromycin

Application(s):OX40 binding molecule (such as anti-OX40 antibody) screening and profiling in a cellular context
Storage:Liquid nitrogen

IV. Description of Host Cell Line
Organism:Cricetulus griseus, hamster, Chinese
Tissue:Ovary
Disease: Hamster Chinese ovary
Morphology: Epitheloid cell
Growth Properties: Adherent

Ⅴ. Representative Data

CBP74038.png

Figure 1. Recombinant CHO stably expressing human OX40 (TNF receptor superfamily member 4, TNFRSF4, ACT35; CD134; IMD16; TXGP1L, GenBank Accession #NM_003327).


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