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药靶细胞株 > 免疫治疗细胞株 > CBP74071TL1A/CHO

TL1A/CHO
名称 TL1A/CHO
型号 CBP74071
报价
特点 TL1A/CHO,冻存条件:90% FBS+10% DMSO;培养基:F12K+10%FBS+600ug/ml hygromycin
  • 详细内容

 TL1A/CHO

CBP74071
I. Background
Tumor necrosis factor (TNF)-like cytokine 1A (TL1A)/TNF superfamily member 15 (TNFSF15) is a proinflammatory cytokine and a member of the TNFα superfamily, as it was originally characterized in a screen for novel molecules with homology to TNFα.
 
II. Description
TL1A is expressed on activated T cells, dendritic cells, and monocytes, as well as induced by TNFα and interleukin (IL)1α in Huvec cells in vitro.In contrast to the TNFα receptors, which are expressed on essentially all cells, the receptor for TL1A, death receptor 3  (DR3), is primarily expressed on T cells, natural killer (NK) cells, and NK T (NKT) cells, thereby limiting the effects of TL1A.
 
III. Introduction
Host Cell:CHO
Expressed gene:TL1A
Stability:32 passages
Freeze Medium:90% FBS+10% DMSO
Culture Medium:F12K+10%FBS+600ug/ml hygromycin
Mycoplasma Testing:Negative
Storage:Liquid nitrogen
Application(s):N/A
 
IV. Description of Host Cell Line
Organism:Cricetulus griseus, hamster, Chinese
Tissue:Ovary
Disease: Hamster Chinese ovary
Morphology: Epitheloid cell
Growth Properties: Adherent
 
Ⅴ. Representative Data

    

Figure 1.Recombinant CHO-cells constitutively expressing  TL1A and an engineered T cell receptor (TCR) activator.

 

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