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药靶细胞株 > 免疫治疗细胞株 > CBP74127PDL1/CD155/TCR Activator/CHO

PDL1/CD155/TCR Activator/CHO
名称 PDL1/CD155/TCR Activator/CHO
型号 CBP74127
报价
特点 PDL1/CD155/TCR Activator/CHO,冻存条件:90% FBS+10% DMSO;
  • 详细内容

 PDL1/CD155/TCR Activator/CHO

CBP74127
I. Background
The binding of Programmed Cell Death Protein 1 (PD-1), a receptor expressed on activated T-cells, to its ligands, PD-L1 and PD-L2, negatively regulates immune responses. PD-1 ligands are found on most cancers, and the PD-1:PD-L1/2 interaction inhibits T-cell activity and enables cancer cells to escape immune surveillance. The PD-1:PD-L1/2 pathway is also involved in regulating autoimmune responses, making these proteins promising therapeutic targets for a number of cancers, as well as multiple sclerosis, arthritis, lupus, and type I diabetes.
 
Recombinant CHO-K1 cells constitutively expressing human CD155 (Poliovirus receptor, Nectin-like protein 5, GenBank accession # NM_006505) and an engineered T cell receptor (TCR) activator.
 
II. Introduction
Expressed gene:PDL1
Stability:32 passages
Freeze Medium:90% FBS+10% DMSO
Culture Medium: 
Mycoplasma Testing:Negative
Storage:Liquid nitrogen
 
III. Representative Data

Figure 1.  Dose Response of Blocking Antibodies in PD-1/TIGIT Dual Effector Reporter Cells (Clone 7) With PD-L1&CD155/ TCR Activator - CHO Cells.

 

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