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药靶细胞株 > 肿瘤免疫细胞株 > CBP74140Claudin18.2/PANC02

Claudin18.2/PANC02
名称 Claudin18.2/PANC02
型号 CBP74140
报价
特点 Claudin18.2/PANC02
  • 详细内容

CBP74140
I. Background

Claudins (CLDNs) are a family of proteins that form tight junctions and maintain the polarity of epithelial and endothelial cells. CLDN18 is specifically expressed in the stomach and lung. Of the two CLDN18 isoform transcripts produced by alternative splicing, CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung specific. CLDN18.2 is a highly selective gastric lineage antigen expressed exclusively on short-lived differentiated gastric epithelial cells where it has only limited accessibility to antibody drugs.14,15 CLDN18.2 is maintained during the course of malignant transformation and thus frequently displayed on the surface of human gastric cancer cells.

II. Introduction

Host Cell:

PANC02

Expressed gene:

Claudin18.2

Stability:32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Freeze Medium:90% FBS+10% DMSO
Culture Medium:

DMEM+10%FBS+5ug/ml puromycin

Mycoplasma Testing:Negative
Storage:Liquid nitrogen
III. Description of Host Cell Line
Species:Mouse
Disease: Mouse pancreatic cancer cell lines
Morphology: Epithelial
Growth Properties: Adherent
IV. Representative Data

1. Claudin18.2/PANC02




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