名称 | PD-L1/CD80 CD86 aAPC Cell |
型号 | CBP74151 |
报价 | ![]() |
特点 | PD-L1/CD80&CD86 aAPC Cell |
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- 详细内容
I. Background | |
免疫检查点抑制剂(抗 CTLA4、抗 PD1、抗 PDL1、抗 PD1/PDL1 与抗 CTLA4 联合治 疗)治疗癌症患者是近年来肿瘤学领域的重大突破,是一种新型的癌症治疗手段。 | |
II. Description | |
PDL1 CD80&CD86 aAPC Cell 作为 PD1&CTLA4 Dual Effector Reporter Cell 的靶细胞,很好的模拟了体内 PD1&CTLA4 的信号转导过程,原理见下图所示。 Figure 1. PDL1 CD80&CD86 aAPC Cell 细胞模型原理图 | |
III. Introduction | |
Expressed gene: | PD-1、CD80、CD86 |
Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Freeze Medium: | 90% FBS+10% DMSO |
Culture Medium: | RPMI-1640+10%FBS+1 μg/ml Puromycin+800 μg/ml Hygromycin B |
Mycoplasma Testing: | Negative |
Storage: | Liquid nitrogen |
Application(s): | Functional(Report Gene) Assay |
IV. Representative Data | |
Figure 1. Dose Response of Blocking Antibodies in PD1&CTLA4 Dual Effector Reporter Cell (C16) With PD-L1 CD80&CD86 aAPC Cell (C14). | |
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