ICOSL/CHO IO细胞株-南京科佰生物科技有限公司

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CBP74068
I. Background
ICOSL is the Ligand for the T-cell-specific cell surface receptor ICOS. When engaged by the ICOSL, the ICOS initiates a costimulatory signal for T-cell proliferation and cytokine production. It also induces B-cell proliferation and differentiation into plasma cells. The ICOS/ICOSL is a major regulator of the adaptive immune responses and also plays an important role in mediating local tissue responses to inflammatory conditions.

II. Description
Recombinant CHO-K1 cells constitutively expressing human ICOSL (also known as human secreted B7 homolog 2 (B7-H2), CD275, ICOSLG, and B7-related protein (B7RP), GenBank Accession No. NM_001283050.

III. Introduction
Host Cell:	CHO, Chinese Hamster Ovary
Expressed gene:	ICOSL
Stability:	32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Synonym(s):	B7 homolog 2, CD275, ICOSL, ICOSLG, B7-related protein (B7RP), B7-H2
Freeze Medium:	90% FBS+10% DMSO
Culture Medium:	F12k+10%FBS+500ug/ml Hygromycin
Mycoplasma Testing:	Negative
Storage:	Liquid nitrogen
Application(s):	Ligand of ICOS&Binding Assay,FACS

IV. Description of Host Cell Line
Organism:	Cricetulus griseus, hamster, Chinese
Tissue:	Ovary
Disease:	Hamster Chinese ovary
Morphology:	Epitheloid cell
Growth Properties:	Adherent

Ⅴ. Representative Data
Figure 1.Recombinant CHO-cells constitutively expressing human ICOSL.