名称 | FBXW7 p.R479Q Reference Standard 标准品 |
型号 | CBP10284 |
报价 | ![]() |
特点 | FBXW7 p.R479Q Reference Standard |
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CBP10284 | |
Format | Genomic DNA |
Description | FBXW7 R479Q lies within the WD 3 repeat region of the Fbxw7 protein (UniProt.org). R479Q confers a loss of FBXW7-substrate interation and impairs substrate degradation by FBXW7, resulting in sustained NICD and MYC expression (PMID: 17646409, PMID: 25450649). |
Technical Data | |
DNA Change | c.1436G>A |
AA Change | p.R479Q |
Mutation type | Substitution - Missense |
Zygosity | Heterozygous |
Allelic Frequency | 66.67% |
Transcript | ENST00000281708 |
Cosmic ID | COSM22974 |
Chr position(GRCh37) | chr4:153247366 |
Buffer | Tris-EDTA |
Product Information | |
Intended Use | Research Use Only |
Unit Size | 1ug |
Concentration | Download for COA |
Purofication | Download for COA |
DNA electrophoresis | Download for COA |
Sanger sequencing | |
Storage | 4℃ |
Expiry | 36 months from the date of manufacture |