名称 | PDGFRA V658A-R558_I565del/Baf3 细胞株 |
型号 | CBP73336 |
报价 | ![]() |
特点 | PDGFRA V658A-R558_I565del/Baf3 |
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药靶细胞株 > kinase激酶细胞株 > CBP73336PDGFRA V658A-R558_I565del/Baf3 细胞株
![PDGFRA V658A-R558_I565del/Baf3 细胞株](http://img80.chem17.com/gxhpic_a89b1029a6/fd9c5b6de14e75b1fb123653623121a25496c3d2fc187e2d898156e7a0eee0305aca001b265ad145.jpg)
- 详细内容
CBP73336 | |
I. Introduction | |
Cell Line Name: | PDGFRA V658A-R558_I565del/Baf3 |
Host Cell: | Ba/F3 |
Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Freeze Medium: | 90% FBS+10% DMSO |
Complete Culture Medium: | RPMI-1640+10%FBS |
Mycoplasma Status: | Negative |
II.Background | |
PDGFRA, platelet-derived growth factor receptor alpha, is a receptor tyrosine kinase that activates PI3K/Akt, RAS/MAPK, and JAK/STAT pathways to promote cell proliferation and survival (PMID: 21605429). PDGFRA mutations have been detected in melanoma, AML, peripheral nerve sheath tumors, sarcoma, and neuroendocrine carcinomas (PMID: 23752188, PMID: 20685895), several fusions have also been reported (PMID: 22432087, PMID: 26276769), and amplification has been observed in glioblastoma (PMID: 23438035). | |
III. Representative Data | |
1.Sanger of PDGFRA V658A-R558_I565del/Baf3 Figure 1. PDGFRA V658A-R558_I565del/Baf3 V658A Figure 2. PDGFRA V658A-R558_I565del/Baf3 Del24 |