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药靶细胞株 > kinase激酶细胞株 > CBP73296c-Kit A502_Y503dup/BaF3

c-Kit A502_Y503dup/BaF3
名称 c-Kit A502_Y503dup/BaF3
型号 CBP73296
报价
特点 c-Kit A502_Y503dup/BaF3,母细胞:BaF3,冻存条件:90% FBS+10% DMSO;ABL1,ABL 原癌基因 1,非受体酪氨酸激酶,通过 ERK5、Rac/JNK 和 Stat1/3 通路在细胞生长调节中发挥作用。已经在各种癌症中报道了 BCR-ABL1 融合蛋白导致组成型激酶活性,并且已经证明 BCR-ABL1 背景下的许多 Abl1 突变会产生耐药性。
  • 详细内容
CBP73296
I. Introduction

Cell Line Name:

c-Kit A502_Y503dup/BaF3

Host Cell:

Ba/F3

Stability:16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

RPMI-1640+10%FBS

Mycoplasma Status:

Negative


II. Background


KIT A502_Y503dup (also referred to as Y503_F504insAY) indicates the insertion of 2 duplicate amino acids, alanine (A)-502 through tyrosine (Y)-503, in the Ig-like C2-type domain 5 (exon 9) of the Kit protein . A502_Y503dup results in constitutive phosphorylation of Kit and is transforming in cell culture.


III. Representative Data

1. WB of c-Kit A502_Y503dup/BaF3


2. Sanger of c-Kit A502_Y503dup/BaF3

3. Anti-proliferation assay

Figure 4. CTG Proliferation Assay of BaF3 C-KIT A502_Y503dup Cells (C5).



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