c-Kit A502_Y503dup/BaF3-南京科佰生物科技有限公司

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Email： zhangxiangwen@cobioer.com

名称	c-Kit A502_Y503dup/BaF3
型号	CBP73296
报价
特点	c-Kit A502_Y503dup/BaF3,母细胞：BaF3，冻存条件：90% FBS+10% DMSO；ABL1，ABL 原癌基因 1，非受体酪氨酸激酶，通过 ERK5、Rac/JNK 和 Stat1/3 通路在细胞生长调节中发挥作用。已经在各种癌症中报道了 BCR-ABL1 融合蛋白导致组成型激酶活性，并且已经证明 BCR-ABL1 背景下的许多 Abl1 突变会产生耐药性。

CBP73296
I. Introduction
Cell Line Name：	c-Kit A502_Y503dup/BaF3
Host Cell:	Ba/F3
Stability:	16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Freeze Medium:	90% FBS+10% DMSO
Complete Culture Medium:	RPMI-1640+10%FBS
Mycoplasma Status:	Negative
II. Background
KIT A502_Y503dup (also referred to as Y503_F504insAY) indicates the insertion of 2 duplicate amino acids, alanine (A)-502 through tyrosine (Y)-503, in the Ig-like C2-type domain 5 (exon 9) of the Kit protein . A502_Y503dup results in constitutive phosphorylation of Kit and is transforming in cell culture.
III. Representative Data
1. WB of c-Kit A502_Y503dup/BaF3
2. Sanger of c-Kit A502_Y503dup/BaF3
3. Anti-proliferation assay Figure 4. CTG Proliferation Assay of BaF3 C-KIT A502_Y503dup Cells (C5).