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药靶细胞株 > kinase激酶细胞株 > CBP73305TEL-KDR/BaF3

TEL-KDR/BaF3
名称 TEL-KDR/BaF3
型号 CBP73305
报价
特点 TEL-KDR/BaF3,母细胞:BaF3,冻存条件:90% FBS+10% DMSO;
  • 详细内容


CBP73305
I. Introduction

Cell Line Name:

TEL-KDR/BaF3

Host Cell:

Ba/F3

Stability:16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)

Application:

Anti-proliferation assay and PD assay

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

RPMI-1640+10%FBS

Mycoplasma Status:

Negative


II.Background

KDR (VEGFR2), kinase insert domain receptor, is also known as vascular endothelial growth factor receptor 2 and is an endothelial cell surface receptor tyrosine kinase and member of the vascular endothelial growth factor family of proteins that plays a role in angiogenesis and cell proliferation through activation of RAF-MEK-MAP and PI3K-AKT pathways (PMID: 25568876, PMID: 29093528, PMID: 26578684). KDR amplification and overexpression have been reported in a variety of tumor types (PMID: 21382095, PMID: 27218826, PMID: 25231439, PMID: 20606037, PMID: 30819137) and somatic mutations have been reported in sarcomas and head and neck squamous cell carcinomas (PMID: 22314185, PMID: 11801954).


III. Representative Data

1.Sanger of TEL-KDR/BaF3

CBP73305.png


2. Anti-proliferation assay

CBP73305-2.png

Figure 2. CTG Proliferation Assay of BaF3 TEL-KDR Cells (C12).



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