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药靶细胞株 > kinase激酶细胞株 > CBP73210TPM3-NTRK1 G667C/BaF3

TPM3-NTRK1 G667C/BaF3
名称 TPM3-NTRK1 G667C/BaF3
型号 CBP73210
报价
特点 TPM3-NTRK1 [G667C]/BaF3,母细胞:BaF3,冻存条件:90% FBS+10% DMSO;
  • 详细内容


CBP73210

I. Introduction

Cell Line Name:

TPM3-NTRK1 [G667C]/BaF3

Host Cell:

BA/F3

Stability:16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)

Application:

Anti-proliferation assay and PD assay

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

RPMI-1640+10%FBS+2ug/ml puromycin

Mycoplasma Status:

Negative

II.Background

NTRK1 rearrangements involve the kinase domain of the NTRK1 gene which includes 17 exons located on chromosome 1q21-22 (Alberti et al. 2003). The frequency of NTRK1 fusions in patients with adenocarcinoma histology is 3.3% of cases (3 out of 91 patients; Vaishnavi et al. 2013).

a In preclinical studies, cell lines expressing MPRIP-NTRK1 or CD74-NTRK1 were inhibited by ARRY-470, a TRKA/B/C inhibitor (Vaishnavi et al. 2013).

b In preclinical studies, cell lines expressing MPRIP-NTRK1 or CD74-NTRK1 were inhibited by lestaurtinib, a FLT3/TRKA inhibitor (Vaishnavi et al. 2013).

c A patient with non-small cell lung cancer harboring an MPRIP-NTRK1 fusion mutation was treated with crizotinib, which has activity against TRKA in addition to ALK, MET and ROS1 (Vaishnavi et al. 2013). The patient demonstrated a small radiographic decrease in tumor size but experienced disease progression after three months (Vaishnavi et al. 2013)


III. Representative Data

1. WB of  TPM3-NTRK1-G667C/BaF3 expression

CBP73210 WB.png


2. Anti-proliferation assay

CBP73210 sanger1.png


Figure 2. SNP of  TPM3-NTRK1-G667C/BaF3

CBP73210 sanger2.jpg


Figure 3. Sanger Sequencing of  TPM3-NTRK1-G667C/BaF3

CBP73210 fig.jpg


Figure 4. CTG Proliferation Assay of BaF3 TPM3-NTRK1 G667C Cells (C1).



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