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药靶细胞株 > kinase激酶细胞株 > CBP73225TPM3-NTRK1 G595R/BaF3

TPM3-NTRK1 G595R/BaF3
名称 TPM3-NTRK1 G595R/BaF3
型号 CBP73225
报价
特点 TPM3-NTRK1 [G595R]/BaF3,母细胞:BaF3,冻存条件:90% FBS+10% DMSO;培养基:1640+10%FBS+2ug/ml puromycin
  • 详细内容

 

CBP73225
I. Introduction

Cell Line Name:

TPM3-NTRK1 [G595R]/BaF3

Gene Synonyms:

TPM3

Host Cell:

Ba/F3

Stability:16 passages

Application:

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

1640+10%FBS+2ug/ml puromycin
 

Mycoplasma Status:

Negative

 
II.Background

TPM3, tropomyosin 3, is a member of the tropomyosin family of actin-interacting proteins, which regulates actin function and plays an essential role in embryonic development (PMID: 23904035, PMID: 26240174). TPM3-NTRK1 fusions are recurrent in colorectal cancer (PMID: 24962792, PMID: 30279230) and additional fusions, with multiple gene partners, have been identified in other tumor types, including inflammatory myofibroblastic tumors (PMID: 10934142), anaplastic large cell lymphoma (PMID: 10216106), renal cell carcinoma (PMID: 32102128), and lung cancer (PMID: 25667280).

 
III. Representative Data

1.TPM3-NTRK1 G595R/BaF3

 

CBP73225 WB.png


2. Anti-proliferation assay

 

CBP73225 fig.jpg


Figure . Anti-proliferation assay of three reference compounds on the TPM3-NTRK1 G595R/BaF3 Stable Cell Line.


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