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药靶细胞株 > 肿瘤免疫细胞株 > CBP7406241BB/NFkB-Luc/Jurkat

41BB/NFkB-Luc/Jurkat
名称 41BB/NFkB-Luc/Jurkat
型号 CBP74062
报价
特点 41BB/NFkB-Luc/Jurkat,母细胞:NFkB reporter Jurkat cells
  • 详细内容


CBP74062
I. Background
Human CD137 (4-1BB; TNFRS9) is an inducible costimulatory molecule that activates T cells. CD137-CD137L mediated signaling has been shown to be important for proliferation, effector functions and survival of T cells. CD137 is also expressed in NK and NKT cells. Antibodies targeting CD137 activation in immune cells have demonstrated potent anti-tumor effects in cancer patients.
II. Description

The NF-κB Luciferase Reporter Lentivirus are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells, including primary and non-dividing cells.

III. Introduction
Host Cell:NFkB reporter Jurkat cells
Expressed gene:41BB
Stability:32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Synonym(s):4-1BB, CD137
Freeze Medium:90% FBS+10% DMSO
Culture Medium:RPMI-1640+10%FBS+800ug/ml hygromycin+1ug/ml puromycin
Mycoplasma Testing:Negative
Storage:Liquid nitrogen
Application(s):Useful for studying protein binding and screening small molecules.
IV. Description of Host Cell Line
Organism:Homo sapiens, human
Tissue:Peripheral blood
Disease: Acute T cell leukemia
Morphology: Lymphoblast
Growth Properties: Suspension
Ⅴ. Representative Data


CBP74062 fig1.png


 COBIOER

Figure 2. 4-1BB/Jurkat (C43) NFkB-Luc report assay stimulated by 4-1BBL.




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