| 名称 | 41BB/NFkB-Luc/Jurkat |
| 型号 | CBP74062 |
| 报价 |  |
| 特点 | 41BB/NFkB-Luc/Jurkat,母细胞：NFkB reporter Jurkat cells |
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电话：4008750250
号码：
手机：18066071954
地址：南京市栖霞区纬地路9号
Email： zhangxiangwen@cobioer.com
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- 详细内容
| CBP74062 | |
| I. Background | |
| Human CD137 (4-1BB; TNFRS9) is an inducible costimulatory molecule that activates T cells. CD137-CD137L mediated signaling has been shown to be important for proliferation, effector functions and survival of T cells. CD137 is also expressed in NK and NKT cells. Antibodies targeting CD137 activation in immune cells have demonstrated potent anti-tumor effects in cancer patients. | |
| II. Introduction | |
| Host Cell: | NFkB reporter Jurkat cells |
| Expressed gene: | 41BB |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Synonym(s): | 4-1BB, CD137 |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | RPMI-1640+10%FBS+800ug/ml hygromycin+1ug/ml puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Functional(Report Gene) Assay |
| III. Description of Host Cell Line | |
| Organism: | Homo sapiens, human |
| Tissue: | Peripheral blood |
| Disease: | Acute T cell leukemia |
| Morphology: | Lymphoblast |
| Growth Properties: | Suspension |
| IV.. Representative Data | |
Figure 1. Recombinant 41BB/NFkB-Luc/Jurkat constitutively expressing 41BB. | |
Figure 2.Detect Luciferase assay by Ultra Luciferase Detection Kit CBPH0001（we strongly suggest to purchase from Cobioer). 4-1BB/Jurkat (C43) NFkB-Luc report assay stimulated by 4-1BBL. | |
