加入收藏 | 设为首页 | 联系我们

产品搜索

相关文章

联系我们

联系人:蒋经理
电话:86-25-86880024
号码:86-25-86880024
手机:18066071954
地址:南京市雨花区长虹路222号
Email: duhaitao@cobioer.com

产品展示 / PRODUCTS
药靶细胞株 > 免疫治疗细胞株 > CBP74120PVRIG(CD112R) Effector Reporter Cell

PVRIG(CD112R) Effector Reporter Cell
名称 PVRIG(CD112R) Effector Reporter Cell
型号 CBP74120
报价
特点 PVRIG(CD112R) Effector Reporter Cell,冻存条件:90% FBS+10% DMSO;培养基:1640+10%FBS+800ug/ml hygromycin+1ug/ml puromycin
  • 详细内容

 PVRIG(CD112R) Effector Reporter Cell

CBP74120
I. Background

PVRIG (CD112R) is an regulatory protein expressed on T-cells which inhibits immune activation when binding to its counterpart on APCs, PVRL2 (CD112, Nectin-2). Since both PVRL2 and PVR can activate DNAM-1 (CD226), PVRIG works synergistically with and separately from TIGIT. PVRL2 is overexpressed in a variety of tumor types, including breast and ovarian cancers, suggesting that its interaction with PVRIG is a major mechanism of immune suppression in those diseases.

 
II. Description
Human secreted CD112R, also known as Poliovirus Receptor-related Immunoglobulin Domain-containing Protein (PVRIG), GenBank Accession No. NM_024070, a.a. 41-172, with C-terminal Fc-Fusion-Avi-tag, expressed in a HEK293 cell expression system and enzymatically biotin-labeled using AviTag technology. MW = 42 kDa. 
 
III. Introduction
Expressed gene:

PVRIG(CD112R)

Stability:32 passages
Synonym(s):Poliovirus Receptor-related Immunoglobulin Domain-containing Protein, Transmembrane Protein PVRIG, 79270-1, 79270-2
Freeze Medium:90% FBS+10% DMSO
Culture Medium:

1640+10%FBS+800ug/ml hygromycin+1ug/ml puromycin

Mycoplasma Testing:Negative
Storage:Liquid nitrogen
 
IV. Representative Data

 

Figure 1. Dose Response of PVRIG Blocking Antibody in PVRIG(CD112R) Effector Reporter Cells (Clone 7) With CD112/TCR Activator - CHO Cells.

如果你对CBP74120PVRIG(CD112R) Effector Reporter Cell感兴趣,想了解更详细的产品信息,填写下表直接与厂家联系:


留言框

  • 产品:

  • 您的单位:

  • 您的姓名:

  • 联系电话:

  • 常用邮箱:

  • 省份:

  • 详细地址:

  • 补充说明:

  • 验证码:

    请输入计算结果(填写阿拉伯数字),如:三加四=7
QQ在线客服
电话咨询
  • 25-86880024
  • 手机:18066071954

化工仪器网

推荐收藏该企业网站
扫一扫访问手机站扫一扫访问手机站
访问手机站