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药靶细胞株 > kinase激酶细胞株 > CBP73351EML4-ALK V1 C1156Y/L1198F/BaF3 kinase

EML4-ALK V1 C1156Y/L1198F/BaF3 kinase
名称 EML4-ALK V1 C1156Y/L1198F/BaF3 kinase
型号 CBP73351
报价
特点 EML4-ALK V1 [C1156Y/L1198F]/BaF3
  • 详细内容
CBP73351
I. Introduction

Cell Line Name:

EML4-ALK V1 [C1156Y/L1198F]/BaF3

Host Cell:

Ba/F3

Stability:16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)

Application:

Anti-proliferation assay and PD assay

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

RPMI-1640+10%FBS

Mycoplasma Status:

Negative

II.Background

EML4-ALK results from the fusion of EML4 and ALK, resulting in constitutive kinase activity, transformation in cultured cells, and tumor activity in mouse models (PMID: 19064915, PMID: 17625570). EML4-ALK fusions have been associated with non-small cell lung cancer (PMID: 26755435).

III. Representative Data

1.WB of EML4-ALK V1 [C1156Y/L1198F]/BaF3


2. Sanger of EML4-ALK V1 [C1156Y/L1198F]/BaF3


Figure 1. EML4-ALK V1 [C1156Y/L1198F]/BaF3 Fusion


Figure 2. EML4-ALK V1 [C1156Y/L1198F]/BaF3 C1156Y

Figure 3. EML4-ALK V1 [C1156Y/L1198F]/BaF3 L1198F

3. Anti-proliferation assay

 COBIOER

Figure 4. CTG Proliferation Assay of BaF3 EML4-ALK V1 [C1156Y/L1198F] (C1).




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