| 名称 | EML4-ALK V1 I1171S/BaF3 kinase |
| 型号 | CBP73354 |
| 报价 |  |
| 特点 | EML4-ALK V1 [I1171S]/BaF3 |
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药靶细胞株 > kinase激酶细胞株 > CBP73354EML4-ALK V1 I1171S/BaF3 kinase
- 详细内容
| CBP73354 | |
| I. Introduction | |
Cell Line Name： | EML4-ALK V1 [I1171S]/BaF3 |
Host Cell: | Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Application: | Anti-proliferation assay and PD assay |
Freeze Medium: | 90% FBS+10% DMSO |
Complete Culture Medium: | RPMI-1640+10%FBS |
Mycoplasma Status: | Negative |
| II.Background | |
EML4-ALK results from the fusion of EML4 and ALK, resulting in constitutive kinase activity, transformation in cultured cells, and tumor activity in mouse models (PMID: 19064915, PMID: 17625570). EML4-ALK fusions have been associated with non-small cell lung cancer (PMID: 26755435). | |
| III. Representative Data | |
1.WB of EML4-ALK V1 [I1171S]/BaF3 | |
2. Sanger of EML4-ALK V1 [I1171S]/BaF3 Figure 1. EML4-ALK V1 [I1171S]/BaF3 Fusion
Figure 2. EML4-ALK V1 [I1171S]/BaF3 I1171S | |
3. Anti-proliferation assay
Figure 3. CTG Proliferation Assay of BaF3 EML4-ALK V1 [l1171S] (C1). | |
![CBP73354 数据图 BaF3 EML4-ALK V1 [I1171S] (C1).jpg](https://img75.chem17.com/gxhpic_a89b1029a6/6fd5d5abffebbb9e88ff0a9bd5ae5469dbc08bcf215484065911c41d9a8df648816d7aa130f74105.jpg "CBP73354 数据图 BaF3 EML4-ALK V1 [I1171S] (C1).jpg")
