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药靶细胞株 > 肿瘤免疫细胞株 > CBP74154SIRPɑ/PD-1 Dual Effector Reporter Cell

SIRPɑ/PD-1 Dual Effector Reporter Cell
名称 SIRPɑ/PD-1 Dual Effector Reporter Cell
型号 CBP74154
报价
特点 SIRPɑ/PD-1 Dual Effector Reporter Cell
  • 详细内容
CBP74154
I. Background
SIRP alpha protein, or Signal regulatory proteinalpha (SIRP-α), also known as Tyrosine protein phosphatase non-receptor type substrate 1, CD172a, Bit, and MyD-1, GenBank Accession No. NM_080792, a.a. 27-370, with C-terminal Avi and His tags, MW 40.3 kDa*. This SIRP alpha protein acts as a receptor for CD47; a.a. 27-370 correspond to the extracellular portion of SIRP-α. *Note: SIRP-α is heavily glycosylated, resulting in higher molecular weight.


The binding of Programmed Cell Death Protein 1 (PD-1), a receptor expressed on activated T-cells, to its ligands, PD-L1 and PD-L2, negatively regulates immune responses. PD-1 ligands are found on most cancers, and the PD-1:PD-L1/2 interaction inhibits T-cell activity and enables cancer cells to escape immune surveillance. The PD-1:PD-L1/2 pathway is also involved in regulating autoimmune responses, making these proteins promising therapeutic targets for a number of cancers, as well as multiple sclerosis, arthritis, lupus, and type I diabetes

II. Introduction
Expressed gene:SIRPɑ、PD-1
Stability:32 passages(in-house test, that not means the cell line will be instable beyond the passages we tested.)
Synonym(s):SIRPɑ、PD-1
Freeze Medium:90% FBS+10% DMSO
Culture Medium:RPMI-1640+10%FBS+2ug/ml puromycin+ 5ug/ml blasticidin+200ug/ml hygromycin
Mycoplasma Testing:Negative
Storage:Liquid nitrogen
Application(s):Functional(Report Gene) Assay
III. Representative Data

CBP74154+CBP74155 新.jpg

Figure 1. Dose response of Blocking Antibodies in SIRPα/PD-1 Dual Effector Reporter Cells(C18) With CD47/PD-L1 Dual Target Cells.








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