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基因检测标准品 > Mutation > CBP10334EGFR p.E746_A750delELREA Reference Standard 标准品

EGFR p.E746_A750delELREA Reference Standard 标准品
名称 EGFR p.E746_A750delELREA Reference Standard 标准品
型号 CBP10334
报价
特点 EGFR p.E746_A750delELREA Reference Standard
  • 详细内容
 CBP10334
FormatGenomic DNA
DescriptionEGFR E746_A750del results in the deletion of five amino acids in the kinase domain of the Egfr protein from amino acids 746 to 750 (PMID: 17318210). E746_A750del results in increased Egfr kinase activity, activation of p44/42 MAPK and AKT in cell culture, promotes tumor growth in xenograft models (PMID: 16373402, PMID: 16912195), and is transforming in cell culture (PMID: 29533785).
  
Technical Data 
DNA Changec.2235_2249del15 GGAATTAAGAGAAGC>-
AA Changep.E746_A750delELREA
Mutation typeDeletion - In frame
ZygosityHeterozygous
Allelic Frequency88.9%
TranscriptENST00000275493
Cosmic IDCOSM6223
Chr position(GRCh37)chr7:55242465_55242479
BufferTris-EDTA
  
Product Information 
Intended UseResearch Use Only
Unit Size1ug
ConcentrationDownload for COA
PuroficationDownload for COA
DNA electrophoresisDownload for COA
Sanger sequencing

CBP10334.jpg

Storage4℃
Expiry36 months from the date of manufacture
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