名称 | EGFR p.E746_A750delELREA Reference Standard 标准品 |
型号 | CBP10335 |
报价 | |
特点 | EGFR p.E746_A750delELREA Reference Standard |
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手机:18066071954
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CBP10335 | |
Format | Genomic DNA |
Description | EGFR E746_A750del results in the deletion of five amino acids in the kinase domain of the Egfr protein from amino acids 746 to 750 (PMID: 17318210). E746_A750del results in increased Egfr kinase activity, activation of p44/42 MAPK and AKT in cell culture, promotes tumor growth in xenograft models (PMID: 16373402, PMID: 16912195), and is transforming in cell culture (PMID: 29533785). |
Technical Data | |
DNA Change | c.2236_2250del15 GAATTAAGAGAAGCA>- |
AA Change | p.E746_A750delELREA |
Mutation type | Deletion - In frame |
Zygosity | Heterozygous |
Allelic Frequency | 97.3% |
Transcript | ENST00000275493 |
Cosmic ID | COSM6225 |
Chr position(GRCh37) | chr7:55242466_55242480 |
Buffer | Tris-EDTA |
Product Information | |
Intended Use | Research Use Only |
Unit Size | 1ug |
Concentration | Download for COA |
Purofication | Download for COA |
DNA electrophoresis | Download for COA |
Sanger sequencing | |
Storage | 4℃ |
Expiry | 36 months from the date of manufacture |
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