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基因检测标准品 > Mutation > CBP10271ERBB2 p.V842I Reference Standard 标准品

ERBB2 p.V842I Reference Standard 标准品
名称 ERBB2 p.V842I Reference Standard 标准品
型号 CBP10271
报价
特点 ERBB2 p.V842I Reference Standard
  • 详细内容

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 CBP10271
FormatGenomic DNA
DescriptionERBB2 (HER2) V842I lies within the protein kinase domain of the Erbb2 (Her2) protein (UniProt.org). V842I results in increased Erbb2 (Her2) activity, downstream Mapk pathway activation, and the ability to transform cells in culture (PMID: 23220880), however in another study, V842I results in similar cell proliferation and viability levels as wild-type Erbb2 (Her2), in two different cell lines (PMID: 29533785).
  
Technical Data 
DNA Changec.2524G>A
AA Changep.V842I
Mutation typeSubstitution - Missense
ZygosityHeterozygous
Allelic Frequency50.00%
TranscriptENST00000269571
Cosmic IDCOSM14065
Chr position(GRCh37)chr17:37881332
BufferTris-EDTA
  
Product Information 
Intended UseResearch Use Only
Unit Size1ug
ConcentrationDownload for COA
PuroficationDownload for COA
DNA electrophoresisDownload for COA
Sanger sequencing

CBP10271.png

Storage4℃
Expiry36 months from the date of manufacture

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