名称 | ERBB2 p.V842I Reference Standard 标准品 |
型号 | CBP10271 |
报价 | ![]() |
特点 | ERBB2 p.V842I Reference Standard |
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电话:86-25-86880024
号码:86-25-86880024
手机:18066071954
地址:南京市雨花区长虹路222号
Email: zhangxiangwen@cobioer.com
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CBP10271 | |
Format | Genomic DNA |
Description | ERBB2 (HER2) V842I lies within the protein kinase domain of the Erbb2 (Her2) protein (UniProt.org). V842I results in increased Erbb2 (Her2) activity, downstream Mapk pathway activation, and the ability to transform cells in culture (PMID: 23220880), however in another study, V842I results in similar cell proliferation and viability levels as wild-type Erbb2 (Her2), in two different cell lines (PMID: 29533785). |
Technical Data | |
DNA Change | c.2524G>A |
AA Change | p.V842I |
Mutation type | Substitution - Missense |
Zygosity | Heterozygous |
Allelic Frequency | 50.00% |
Transcript | ENST00000269571 |
Cosmic ID | COSM14065 |
Chr position(GRCh37) | chr17:37881332 |
Buffer | Tris-EDTA |
Product Information | |
Intended Use | Research Use Only |
Unit Size | 1ug |
Concentration | Download for COA |
Purofication | Download for COA |
DNA electrophoresis | Download for COA |
Sanger sequencing | |
Storage | 4℃ |
Expiry | 36 months from the date of manufacture |