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基因检测标准品 > Mutation > CBP10277EZH2 p.Y646S Reference Standard 标准品

EZH2 p.Y646S Reference Standard 标准品
名称 EZH2 p.Y646S Reference Standard 标准品
型号 CBP10277
报价
特点 EZH2 p.Y646S Reference Standard
  • 详细内容

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 CBP10277
FormatGenomic DNA
DescriptionEZH2 Y646S (corresponds to Y641S in the canonical isoform) lies within a SET domain of the Ezh2 protein (UniProt.org). Y646S confers a gain of function to the Ezh2 protein, as demonstrated by altered substrate specificity, increased catalytic efficiency for H3K27 trimethylation (PMID: 21190999), and is transforming in cell culture (PMID: 25493630).
  
Technical Data 
DNA Changec.1937A>C
AA Changep.Y646S
Mutation typeSubstitution - Missense
ZygosityHeterozygous
Allelic Frequency33.33%
TranscriptENST00000320356
Cosmic IDCOSM37029
Chr position(GRCh37)chr7:148508727
BufferTris-EDTA
  
Product Information 
Intended UseResearch Use Only
Unit Size1ug
ConcentrationDownload for COA
PuroficationDownload for COA
DNA electrophoresisDownload for COA
Sanger sequencing

CBP10277.png

Storage4℃
Expiry36 months from the date of manufacture

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