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基因检测标准品 > Mutation > CBP10186TP53 p.R280K Reference Standard 标准品

TP53 p.R280K Reference Standard 标准品
名称 TP53 p.R280K Reference Standard 标准品
型号 CBP10186
报价
特点 TP53 p.R280K Reference Standard
  • 详细内容

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 CBP10186
FormatGenomic DNA
DescriptionTP53 R280K lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). R280K results in decreased activation and repression of wild-type Tp53 target genes (PMID: 17070499, PMID: 16322760, PMID: 18472962), as well as a gain-of-function in activation of novel targets, and leads to increased cell migration and invasion, and increased cell survival (PMID: 18472962, PMID: 24763051).
  
Technical Data 
DNA Changec.839G>A
AA Changep.R280K
Mutation typeSubstitution - Missense
ZygosityHomozygous
Allelic Frequency100%
TranscriptENST00000269305
Cosmic IDCOSM10728
Chr position(GRCh37)chr17:7577099
BufferTris-EDTA
  
Product Information 
Intended UseResearch Use Only
Unit Size1ug
ConcentrationDownload for COA
PuroficationDownload for COA
DNA electrophoresisDownload for COA
Sanger sequencingDownload for COA
Storage4℃
Expiry36 months from the date of manufacture

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