NGF/hTRKA Effector Reporter Cell-南京科佰生物科技有限公司

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名称	NGF/hTRKA Effector Reporter Cell
型号	CBP74174
报价
特点	NGF/hTRKA Effector Reporter Cell

CBP74174
I. Background
NGF (Nerve Growth Factor) is a Protein Coding gene. Diseases associated with NGF include Neuropathy, Hereditary Sensory And Autonomic, Type V and Autonomic Neuropathy. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and p75 NTR receptor-mediated signalling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and obsolete signal transducer activity, downstream of receptor. An important paralog of this gene is NTF3. TrkA gene expression is under positive feedback from NGF signaling, and this pathway most likely is disrupted in AD by diminished retrograde transport of cortical NGF to CBF consumer neurons.

II.Introduction
Expressed gene:	NGF、TRKA
Stability:	32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Synonym(s):	nerve growth factor (beta polypeptide), NGFB
Freeze Medium:	90% FBS+10%DMSO
Culture Medium:	N/A
Mycoplasma Testing:	Negative
Storage:	Liquid nitrogen
Application(s):	Functional(Report Gene) Assay


III. Representative Data
Figure 1.Dose Response of Recombinant Human NGF in NGF/TRKA Effector Reporter Cells(Clone21).
Figure 2.Inhibition of hNGF-induced Reporter Activity By TRKA Inhibitor in NGF/hTRKA Effector Reporter Cells(Clone 21). Figure 3.Inhibition of hNGF-induced Reporter Activity By NGF Neutralization Ab in NGF/hTRKA Effector Reporter Cells(Clone 21).