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药靶细胞株 > kinase激酶细胞株 > CBP73241FLT3-ITD D835del/BaF3

FLT3-ITD D835del/BaF3
名称 FLT3-ITD D835del/BaF3
型号 CBP73241
报价
特点 FLT3-ITD [D835del]/BaF3,母细胞:BaF3,冻存条件:90% FBS+10% DMSO
  • 详细内容


CBP73241
I. Introduction

Cell Line Name:

FLT3-ITD [D835del]/BaF3

Host Cell:

Ba/F3

Stability:16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

RPMI-1640+10%FBS+2ug/ml puromycin

Mycoplasma Status:

Negative

II.Background

FLT3, receptor-type tyrosine-protein kinase FLT3, activates Akt, Ras, and Erk pathways to regulate differentiation, proliferation, and survival of hematopoietic progenitor cells (PMID: 29316714, PMID: 28538663). Activating mutations of FLT3 are common in hematologic tumors (PMID: 19467916) and the internal tandem duplication (ITD) mutation is commonly observed in acute myeloid leukemia (PMID: 30181385).

III. Representative Data

1.FLT3-ITD [D835del]/BaF3

2. Anti-proliferation assay

Figure . Anti-proliferation assay of three reference compounds on the FLT3-ITD [D835del]/BaF3 Stable Cell Line.



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