名称 | AI-Edigene® IDH2 p.R140Q Reference Standard P |
型号 | CBP10513 |
报价 | |
特点 | AI-Edigene® IDH2 p.R140Q Reference Standard Plus |
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手机:18066071954
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CBP10513 | |
Format | Genomic DNA |
Description | IDH2 R140Q lies within the substrate binding region of the Idh2 protein (UniProt.org). R140Q confers a gain of function to Idh2, enabling conversion of alpha-ketoglutarate to the onco-metabolite 2HG (R(-)-2-hydroxyglutarate), results in increased 2HG levels in patient samples, and is transforming in cell culture (PMID: 20171147, PMID: 23558173). |
Technical Data | |
DNA Change | c.419G>A |
AA Change | p.R140Q |
Mutation type | Substitution - Missense |
Zygosity | Homozygous |
Allelic Frequency | 100% |
Transcript | NM_002168.4 |
Cosmic ID | COSM41590 |
Chr position(GRCh37) | chr15:90631934 |
Buffer | Tris-EDTA |
Product Information | |
Intended Use | Research Use Only |
Unit Size | 1ug |
Concentration | Download for COA |
Purofication | Download for COA |
DNA electrophoresis | Download for COA |
Sanger sequencing | |
Storage | 4°C |
Expiry | 36 months from the date of manufacture |
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