名称 | BRAF p.G469R Reference Standard 标准品 |
型号 | CBP10236 |
报价 | 900 |
特点 | BRAF p.G469R Reference Standard |
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手机:18066071954
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Email: zhangxiangwen@cobioer.com
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CBP10236 | |
Format | Genomic DNA |
Description | BRAF G469R is a hotspot mutation within the protein kinase domain of the Braf protein (UniProt.org). G469R demonstrates intermediate BRAF kinase activity (PMID: 28783719) and results in constitutive ERK activation in cell culture (PMID: 24920063), and in one of two cell lines leads to increased cell proliferation and cell viability compared to wild-type Braf (PMID: 29533785), and is therefore predicted to confer a gain of function to the Braf protein. |
Technical Data | |
DNA Change | c.1405G>A |
AA Change | p.G469R |
Mutation type | Substitution - Missense |
Zygosity | Heterozygous |
Transcript | ENST00000288602 |
Cosmic ID | COSM457 |
Chr position(GRCh37) | chr7:140481403 |
Buffer | Tris-EDTA |
Product Information | |
Intended Use | Research Use Only |
Unit Size | 1ug |
Concentration | Download for COA |
Purofication | Download for COA |
DNA electrophoresis | Download for COA |
Sanger sequencing | Download for COA |
Storage | 4℃ |
Expiry | 36 months from the date of manufacture |