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基因检测标准品 > Mutation > CBP10236BRAF p.G469R Reference Standard 标准品

BRAF p.G469R Reference Standard 标准品
名称 BRAF p.G469R Reference Standard 标准品
型号 CBP10236
报价 900
特点 BRAF p.G469R Reference Standard
  • 详细内容


CBP10236
FormatGenomic DNA
DescriptionBRAF G469R is a hotspot mutation within the protein kinase domain of the Braf protein (UniProt.org). G469R demonstrates intermediate BRAF kinase activity (PMID: 28783719) and results in constitutive ERK activation in cell culture (PMID: 24920063), and in one of two cell lines leads to increased cell proliferation and cell viability compared to wild-type Braf (PMID: 29533785), and is therefore predicted to confer a gain of function to the Braf protein.
  
Technical Data 
DNA Changec.1405G>A
AA Changep.G469R
Mutation typeSubstitution - Missense
ZygosityHeterozygous
TranscriptENST00000288602
Cosmic IDCOSM457
Chr position(GRCh37)chr7:140481403
BufferTris-EDTA
  
Product Information 
Intended UseResearch Use Only
Unit Size1ug
ConcentrationDownload for COA
PuroficationDownload for COA
DNA electrophoresisDownload for COA
Sanger sequencingDownload for COA
Storage4℃
Expiry36 months from the date of manufacture


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