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基因检测标准品 > Mutation > CBP10242BRAF p.G596R Reference Standard 标准品

BRAF p.G596R Reference Standard 标准品
名称 BRAF p.G596R Reference Standard 标准品
型号 CBP10242
报价
特点 BRAF p.G596R Reference Standard
  • 详细内容

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 CBP10242
FormatGenomic DNA
DescriptionBRAF G596R lies within the protein kinase domain of the Braf protein, within the DFG motif (PMID: 19735675). G596R results in impaired Braf kinase activity and decreased Mek and Erk phosphorylation, including in the presence of BRAF V600E, is not transforming in culture and does not promote tumor formation in mouse models, but results in activation of Erk in the presence of CRAF (PMID: 19735675, PMID: 28783719), however, in another study demonstrates similar cell proliferation and viability levels to wild-type Braf (PMID: 29533785), and is predicted to confer a loss of function to the Braf protein.
  
Technical Data 
DNA Changec.1786G>C
AA Changep.G596R
Mutation typeSubstitution - Missense
ZygosityHeterozygous
Allelic Frequency33.33%
TranscriptENST00000288602
Cosmic IDCOSM469
Chr position(GRCh37)chr7:140453149
BufferTris-EDTA
  
Product Information 
Intended UseResearch Use Only
Unit Size1ug
ConcentrationDownload for COA
PuroficationDownload for COA
DNA electrophoresisDownload for COA
Sanger sequencingDownload for COA
Storage-20℃
Expiry36 months from the date of manufacture

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