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基因检测标准品 > Mutation > CBP10470AI-Edigene® NRAS p.G12D Reference Standard Pl

AI-Edigene® NRAS p.G12D Reference Standard Pl
名称 AI-Edigene® NRAS p.G12D Reference Standard Pl
型号 CBP10470
报价
特点 AI-Edigene® NRAS p.G12D Reference Standard Plus
  • 详细内容
 CBP10470
FormatGenomic DNA
DescriptionNRAS G12D is a hotspot mutation that lies within a GTP-binding region of the Nras protein (UniProt.org). G12D confers a loss of function on Nras protein as indicated by decreased intrinsic GTPase activity, reduced sensitivity to GTPase-activating proteins, leading to accumulation of GTP-bound Nras, activation of downstream signaling, and transformation of cultured cells (PMID: 19075190, PMID: 25252692).
  
Technical Data 
DNA Change:c.35G>A
AA Changep.G12D
Mutation typeSubstitution - Missense
ZygosityHomozygous
Allelic Frequency100%
TranscriptENST00000369535
Cosmic IDCOSM564
Chr position(GRCh37)chr1:115258747
Buffer:Tris-EDTA
  
Product Information 
Intended UseResearch Use Only
Unit Size1ug
ConcentrationDownload for COA
PurityDownload for COA
DNA electrophoresisDownload for COA
Sanger sequencing

10470.png

Storage4℃
Expiry36 months from the date of manufacture

 

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